This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison
LDLR Protein Homology
Using the gene homologs to the human LDLR gene found using HomoloGene, protein homology was further analyzed using BLAST. The blastp algorithm was used to determine amino acid sequence similarity for all homologous species.
Pan troglodytes (Chimpanzee)--LDLR
Protein Accession Number--XP_001167447.1
Protein Length--860 amino acids
E-value--0.0
Bos taurus (Cow)--LDLR
Protein Accession Number--XP_874020.1
Protein Length--845 amino acids
E-value--0.0
Mus musculus (Mouse)--Ldlr
Protein Accession Number--NP_034830.2
Protein Length--862 amino acids
E-value--0.0
Rattus norvegicus (Rat)--Ldlr
Protein Accession Number--NP_786938.1
Protein Length--879 amino acids
E-value--0.0
Danio rerio (Zebrafish)--ldlr
Protein Accession Number--NP_001025454.1
Protein Length--911 amino acids
E-value--0.0
Protein Accession Number--XP_001167447.1
Protein Length--860 amino acids
E-value--0.0
Bos taurus (Cow)--LDLR
Protein Accession Number--XP_874020.1
Protein Length--845 amino acids
E-value--0.0
Mus musculus (Mouse)--Ldlr
Protein Accession Number--NP_034830.2
Protein Length--862 amino acids
E-value--0.0
Rattus norvegicus (Rat)--Ldlr
Protein Accession Number--NP_786938.1
Protein Length--879 amino acids
E-value--0.0
Danio rerio (Zebrafish)--ldlr
Protein Accession Number--NP_001025454.1
Protein Length--911 amino acids
E-value--0.0
Analysis
The amino acid sequences for all homologous species gave E-values of 0.0 when compared to the human sequence. This demonstrates that the LDLR protein is highly conserved among human homologs. Although the DNA and mRNA sequences have longer sequences in high order species, the protein has remained fairly constant in length. The function of the protein can therefore be considered similar across all homologs.
